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Enhanced autophagy in renal IR injury appears to act as a compensatory mechanism to mitigate the damaging consequences of IR injury and the progression to AKI 60
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The improved antioxidant enzymes activity and GSH content of tissues have been also reported after riboflavin administration in rat models of migraine (GSH, microsomal GPx) (Reference Btn, Nazrolu and Demirci24) , hepatotoxicity (CAT, SOD and GSH) (Reference Al-Harbi, Imam and Nadeem25,Reference Bashandy, Ebaid and Moussa26) , ulcerative colitis (SOD and GSH) (Reference Karakoyun, Erta and Yksel27) , anticancer drug-induced toxicity (CAT, SOD and GSH) (Reference Naseem, Hassan and Alhazza28,Reference Salman and Naseem29) , spinal cord injury (SOD and GSH) (Reference Sakarcan, Erahin and Eminolu30) , diabetes (GR, SOD, CAT and GSH) (Reference Alam, Iqbal and Naseem31) and abdominal aortic aneurysm (SOD) (Reference Yu, Morimoto and Yu32)
